Regulation of microglial proliferation during chronic neurodegeneration
An common aspect of chronic neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Huntington’s and prion disease, is the amplification of the microglial population .
Control of adult neurogenesis during chronic neurodegeneration
Neurogenesis is increased during acute and chronic neurodegeneration, with the potential to replace damaged neurons at the sites of neuronal loss.
Inflammation in chronic neurodegeneration and the contribution of systemic inflammation
We are interested in understanding the impact of systemic inflammatory events on the progression of neurodegenerative diseases like Alzheimer’s
Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer’s Disease
Oligodendrocyte progenitor cells (OPCs) may be altered in Alzheimer’s disease, and we aim to understand how this population is regulated in pathological conditions.
Understanding microglial dynamics in the healthy and ageing brain
Microglial cells are the resident immune cells of the brain and play crucial roles in the regulation of normal and pathological neural functions, and we aim to understand the balance of the numbers of microglial cells from development to ageing.