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Below you will find our publications (lab members in bold), linking to open access pdf files.



Hu, Y., Fryatt, G. L., Ghorbani, M., Obst, J., Menassa, D., Martin estebane, M., Muntslag, T. A. O., Olmos alonso, A., Guerrero Carrasco, M., Thomas, D., Cragg, M., & Gomez-Nicola, D. (2021). Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathologyCell Reports

Li, T., Zhao, J., Xie, W., Yuan, W., Guo, J., Gan, W-B., Pang, S., Gomez-Nicola, D., & Zhang, S. (2021). Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damageJournal of Neuroinflammation18(1), [81].

Chacon-De-La-Rocha, I., Fryatt, G. L., Rivera, A. D., Restani, L., Caleo, M., Gomez-Nicola, D., & Butt, A. M. (2021). The synaptic blocker botulinum toxin A decreases the density and complexity of oligodendrocyte precursor cells in the adult mouse hippocampusJournal of Neuroscience Research


Chacon-De La Rocha, I., Fryatt, G., Rivera, A. D., Verkhratsky, A., Raineteau, O., Gomez-Nicola, D., & Butt, A. M. (Accepted/In press). Accelerated dystrophy and decay of oligodendrocyte precursor cells in the APP/PS1 model of Alzheimer’s-like pathologyFrontiers in Cellular Neuroscience14, [575082].


Obst, J., Simon, E., Martin Estebane, M., Pipi, E., Barkwill, L. M., Gonzalez-Rivera, I., Buchanan, F., Prescott, A., Faust, D., Fox, S., Brownlees, J., Taylor, D., Perry, V. H., Nuthall, H., Atkinson, P. J., Karran, E., Routledge, C., & Gomez-Nicola, DInhibition of IL-34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in a model of chronic neurodegenerationFrontiers in Immunology


Martin Estebane, M., & Gomez-Nicola, D. Targeting microglial population dynamics in Alzheimer’s disease: are we ready for a potential impact on immune function? Frontiers in Cellular Neuroscience. 2020 Jun 5;14:149. doi: 10.3389/fncel.2020.00149. eCollection 2020.PMID: 32581720 


Carroll, L., Braeutigam, S., Dawes, J. M., Krsnik, Z., Kostovic, I., Coutinho, E., Dewing, J.M., Horton, C.A., Gomez-Nicola, D., Menassa, D. (2020). Autism spectrum disorders: multiple routes to, and multiple consequences of, abnormal synaptic function and connectivityThe Neuroscientist. DOI: 10.1177/1073858420921378


Vanzulli, I., Papanikolaou, M., Chacon De La Rocha, I., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A. Rodriguez, J.J., Butt, A. M. (2020). Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer’s diseaseNeurobiology of Aging. DOI: 10.1016/j.neurobiolaging.2020.05.016


Mecha, M., Yanguas-Casás, N., Feliú, A., Mestre, L., Carrillo-Salinas, F. J., Riecken, K., Gomez-Nicola, D., Guaza, C. (2020). Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesisJournal of Neuroinflammation17(1), [88]. DOI: 10.1186/s12974-020-01734-3


Pegasiou, C-M., Zolnourian, A., Gomez-Nicola, D., Deinhardt, K., Nicoll, J., Ahmed, A., Vajramani, G.V., Grundy, P., Verhoog, M., Mansvelder, H., Perry, V. H., Bulters, D., Vargas-Caballero, M (2020). Age dependent changes in synaptic NMDA receptor composition in adult human cortical neurons. Cerebral Cortex, [bhaa052]. DOI: 10.1093/cercor/bhaa052



Mancuso, R., Fryatt, G., Cleal, M. E., Obst, J., Pipi, E., Monzon-Sandoval, J., …, Gomez-Nicola, D., Perry, V. H. (2019). CSF1R inhibition by JNJ-40346527 alters microglial proliferation and phenotype and results in attenuation of neurodegeneration in P301S mice. Brain. DOI: 10.1093/brain/awz241


Gomez-Nicola, D., Fryatt, G. L., & Askew, K. E. (2019). Measuring microglial turnover in the adult brain. In O. Garaschuk, & A. Verkhratsky (Eds.), Microglia (Vol. 2034, pp. 207-215). Methods in Molecular Biology. New York, NY: Humana. DOI: 10.1007/978-1-4939-9658-2_15


NIMA Consortium (2019). Inflammatory biomarkers in Alzheimer’s disease plasma. Alzheimer’s & Dementia, 15(6), 776-787. DOI: 10.1016/j.jalz.2019.03.007


Sri, S., Pegasiou, C-M., Cave, C-A., Hough, K., Wood, N., Gomez-Nicola, D., Deinhardt K, Bannerman D, Perry VH, Vargas-Caballero, M. (2019). Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease. Acta Neuropathologica Communications, 7(25). DOI: 10.1186/s40478-019-0670-1




Obst, J., Mancuso, R., Simon, E. & Gomez-Nicola, D. (2018). PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration. Brain, Behavior and Immunity. DOI: 10.1016/j.bbi.2018.08.006


Menassa, D. A., & Gomez-Nicola, D. (2018). Microglial dynamics during human brain development. Frontiers in Immunology, 9 (1104). DOI: 10.3389/fimmu.2018.01014


Nunez, J. A., Goring, A., Gomez-Nicola, D., Javaheri, B., Pitsillides, A. A., Thurner, P., … Clarkin, C. (2018). Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age. European Cells & Materials, 35, 281-299. DOI: 10.22203/eCM.v035a20


Schetters, S. T. T., Gomez-Nicola, D., Garcia-Vallejo, J. J., & Van Kooyk, Y. (2018). Neuroinflammation: microglia and T cells get ready to tango. Frontiers in Immunology, 1-11. DOI: 10.3389/fimmu.2017.01905



Lopez-Atalaya, J., Askew, K., Sierra, A., & Gomez-Nicola, D. (2017). Development and maintenance of the brain’s immune toolkit: microglia and non-parenchymal brain macrophages. Developmental Neurobiology. DOI: 10.1002/dneu.22545


The role of microglia in prion diseases: a paradigm of functional diversity
Obst, J., Simon, E., Mancuso, R., Gomez-Nicola, D. Frontiers in Ageing Neuroscience. 2017. doi: 10.3389/fnagi.2017.00207


STING activation reverses lymphoma-mediated resistance to antibody immunotherapy
Dahal, L. N., Dou, L., Hussain, K., Liu, R., Earley, A., Cox, K. L., Murinello, S., Tracy, I., Forconi, F., Steele, A. J., Duriez, P., Gomez-Nicola, D., Teeling, J. L., Glennie, M. J., Cragg, M. S. & Beers, S. A. Cancer Research. 2017. doi: 10.1158/0008-5472.CAN-16-2784


A story of birth and death: insights into the formation and dynamics of the microglial population
Askew, K. and Gomez-Nicola, D. Brain, Behavior and Immunity. 2017. doi:10.1016/j.bbi.2017.03.009


Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation
Clayton, E.L., Mancuso, R., Nielsen, T.T., Mizielinska, S., Holmes, H., Powell, N., Norona, F., Larsen, J.O., Milioto, C., Wilson, K.M., Lythgoe, M.F., Ourselin, S., Nielsen, J.E., Johannsen, P., Holm, I., Collinge, J., Frej, A., Oliver, P.L., Gomez-Nicola, D. and Isaacs, A.M. Human Molecular Genetics. 2017. doi:10.1093/hmg/ddx003


Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain
Askew, K., Li, K., Olmos Alonso, A., Garcia-Moreno , F., Liang, Y., Richardson, P., Tipton, T., Chapman, M., Riecken, K., Beccari, S., Sierra, A., Molnar, Z., Cragg, M.S., Garaschuk, O., Perry, V.H. and Gomez-Nicola, DCell Reports. 2017. doi: 10.1016/j.celrep.2016.12.041

*Comment in AlzForum “Ageing causes identity crisis in microglia”



Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling
Abiega, O., Beccari, S., Diaz-Aparicio , I., Nadjar, A., Laye, S., Leyrolle, Q., Gomez-Nicola, D., Domercq, M., Perez-Samartin, A., Sanchez-Zafra, V., Paris, I., Valero, J., Savage, J.C., Hui, C.W., Tremblay, M.E., Deudero, J.J.P., Brewster, A.L., Anderson, A.E., Zaldumbide, L., Galbarriatu, L., Marinas, A., Vivanco, M.D.M., Matute, C., Maletic-Savatic, M., Encinas, J.M. and Sierra, A. PLoS Biology. 2016. doi: 10.1371/journal.pbio.1002466


CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerve

Martinez-Muriana, A, Mancuso, R, Francos-Quijorna, I, Olmos-Alonso, A, Osta, R, Perry, VH, Navarro, X, Gómez-Nicola, D and Lopez-Vales, R. Scientific Reports. 2016. doi: 10.1038/srep25663


Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb
Liang, Y, Li, K, Riecken, K, Maslyukov, A, Gómez-Nicola, D, Kovalchuk, Y, Fehse, B and Garaschuk, O. Cell Research. 2016. doi: 10.1038/cr.2016.55


The use of human neurons for novel drug discovery in dementia research
Vargas-Caballero, M, Willaime-Morawek, S, Gómez-Nicola, D, Perry, VH, Bulters, D and Mudher, A. Expert Opinion on Drug Discovery. 2016. doi: 10.1517/17460441.2016.1154528


Dark microglia: a new phenotype predominantly associated with pathological states
Bisht , K, Sharma, KP, Lecours, C, Sánchez, MG, El Hajj, H, Milior, G, Olmos-Alonso, A, Gómez-Nicola, D, Luheshi, G, Vallières, L, Branchi, I, Maggi, L, Limatola, C, Butovsky, O and Tremblay, ME. Glia. 2016. doi: 10.1002/glia.22966


Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
Olmos-Alonso, A, Schetters, STT, Sri, S, Askew, K, Mancuso, R, Vargas-Caballero, M, Holscher, C, Perry, VH and Gómez-Nicola, D. Brain. 2016. doi: 10.1093/brain/awv379

*Featured in “Blocking microglial proliferation halts Alzheimer disease in mice”. Nature Reviews in Neurology. 12, 64  doi:10.1038/nrneurol.2016.6



Microglia regulate hippocampal neurogenesis during chronic neurodegenerationDe Lucia, C, Rinchon, A, Olmos-Alonso, A, Riecken, K, Fehse, B, Boche, D, Perry, VH and Gómez-Nicola, DBrain Behaviour and Immunity. 2015. doi: 10.1016/j.bbi.2015.11.001

The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning – Zaru, R, Matthews, SP, Edgar, AJ, Prescott, AR, Gómez-Nicola, D, Hanauer, A and Watts, C. The Journal of Immunology. 2015. doi: 10.4049/?jimmunol.1501520

Analysis of microglial proliferation in Alzheimer’s diseaseGómez-Nicola, D and Perry, VH, Castrillo, JI and Oliver, SG. (eds.) Methods in Molecular Biology. 2015. doi: 10.1007/978-1-4939-2627-5_10

Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s diseaseGómez-Nicola, D and Boche, D. Alzheimer’s Research & Therapy. 2015. doi: 10.1186/s13195-015-0126-

Multicolor RGB marking allows morphometric and functional analysis of hippocampal granule neurons at the single-cell levelGómez-Nicola, D, Riecken, K, Perry, VH and Fehse, B. Human Gene Therapy. 2015. doi: 10.1089/hum.2015.010

Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity Gómez-Nicola, D and Perry, VH. The Neuroscientist. 2015. doi:10.1177/1073858414530512


In-vivo RGB marking and multicolour single-cell tracking in the adult brainGómez-Nicola, D, Riecken, K, Fehse, B and Perry, VH. Scientific Reports. 2014. doi: 10.1038/srep07520

How can we exploit the brain’s ability to repair itself? – Miller, V and Gómez-Nicola, D. Expert Review of Neurotherapeutics. 2014. doi: 10.1586/14737175.2014.985659

Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion diseaseGómez-Nicola, D, Schetters, STT and Perry, VH. Glia. 2014. doi: 10.1002/glia.22660

Temporal dynamics of hippocampal neurogenesis in chronic neurodegenerationGómez-Nicola, D, Suzzi, S, Vargas-Caballero, M, Fransen, NL, Al-Malki, H, Cebrian-Silla, A, García-Verdugo, JM, Riecken, K, Fehse, B and Perry, VH. Brain. 2014. doi: 10.1093/brain/awu155


Regulation of microglial proliferation during chronic neurodegenerationGómez-Nicola, D, Fransen, NL, Suzzi, S and Perry, VH. The Journal of Neuroscience. 2013. doi: 10.1523/JNEUROSCI.4440-12.2013

Editorial. The role of inflammatory mediators in immune-to-brain communication during health and diseaseGómez-Nicola, D, Teeling, J, Guaza, C, Godbout, JP and Taub, DD. Mediators of Inflammation. 2013. doi: 10.1155/2013/429231


Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells – Burgos, E, Gómez-Nicola, D, Pascual, D, Martín, MI, Nieto-Sampedro, M and Goicoechea, C. European Journal of Pharmacology. 2012. doi: 10.1016/j.ejphar.2012.02.008


Interleukin-15 regulates proliferation and self-renewal of adult neural stem cellsGómez-Nicola, D, Valle-Argos, B, Pallas-Bazarra, N and Nieto-Sampedro, M. Molecular Biology of the Cell. 2011. doi: 10.1091/mbc.E11-01-0053

Neurostatin blocks glioma cell cycle progression by inhibiting EGFR activation – Valle-Argos, B, Gómez-Nicola, D and Nieto-Sampedro, M. Molecular and Cellular Neuroscience. 2011. doi: 10.1016/j.mcn.2010.08.009

Inhibitors of glioma growth that reveal the tumour to the immune system – Nieto-Sampedro, M, Valle-Argos, B, Gómez-Nicola, D, Fernández-Mayoralas, A and Nieto-Díaz, M. Clinical Medicine Insights Oncology. 2011. doi: 10.4137/CMO.S7685


Glioma growth inhibition by neurostatin and O-But GD1b – Valle-Argos, B, Gómez-Nicola, D and Nieto-Sampedro, M. Neuro-Oncology. 2010. doi: 10.1093/neuonc/noq073

CCR7 is expressed in astrocytes and upregulated after an inflammatory injuryGómez-Nicola, D, Pallas-Bazarra, N, Valle-Argos, B and Nieto-Sampedro, M. Journal of Neuroimmunology. 2010. doi: 10.1016/j.jneuroim.2010.06.018

Synthesis and characterization of neurostatin-related compounds with high inhibitory activity of glioma growth – Valle-Argos, B, Gómez-Nicola, D and Nieto-Sampedro, M. European Journal of Medicinal Chemistry. 2010. doi: 10.1016/j.ejmech.2010.01.015

Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout miceGómez-Nicola, D, Spagnolo, A, Guaza, C and Nieto-Sampedro, M. Experimental Neurology. 2010. doi: 10.1016/j.expneurol.2009.12.034

Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine releaseGómez-Nicola, D, Valle-Argos, B and Nieto-Sampedro, M. Glia. 2010. doi: 10.1002/glia.20920


Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltrationGómez-Nicola, D, Valle-Argos, B, Suardíaz, M, Taylor, JS and Nieto-Sampedro, M. Journal of Neurochemistry. 2008. doi: 10.1111/j.1471-4159.2008.05746.x

Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.Gómez-Nicola, D, Valle-Argos, B, Pita-Thomas, DW and Nieto-Sampedro, M. Glia. 2008. doi: 10.1002/glia.20628


Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15Gómez-Nicola, D, Doncel-Pérez, E and Nieto-Sampedro, M. Journal of Neuroscience Research. 2006. doi: 10.1002/jnr.20777